DTIC AD1026485: NFAT Signaling and the Tumorigenic pdf

DTIC AD1026485: NFAT Signaling and the Tumorigenic

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Although the importance of microenvironment in prostate cancer is widely recognized, the molecular and cellular processes leading from genetic changes in the prostatic epithelium to the establishment of a tumorigenic microenvironment for prostate cancer is unclear in most contexts. With our finding of NFATc1 being an oncogene and has a potential role in prostate cancer, we proposed to study two main areas (divided into 3 specific aims). First, the detailed study of the tumorigenic microenvironment and the correlation between NFATc1 and prostate cancer status in humans will help facilitate the development of clinically useful biomarkers for both diagnostic and prognostic purposes. Many of the factors we are targeting in the prostate cancer microenvironment are secreted factors that may be present in serum and/or urine at measurable levels, making them suitable for the development of non-invasive clinical tests. Second, the illustration of the main cellular and molecular components in the tumorigenic microenvironment provides new druggable targets aimed at reversing the effects of the alterations in the microenvironment

• Creator/s: Defense Technical Information Center
• Date: 10/1/2016
• Year: 2016
• Book Topics/Themes: DTIC Archive, Chen, Feng, Washington University St. Louis United States, cell physiological processes, carcinoma, cell movement, cultured cells, neoplasms, prostate cancer, cell line, tissues, therapeutics, cellular structures, epithelial cells, oncology, proteins, biological factors, cytoskeleton, peptides, transcription factors, GENETIC MARKERS

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