DTIC AD1046772: Potential Application of Viral Empty pdf

DTIC AD1046772: Potential Application of Viral Empty

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The goal of this project has been to test the hypothesis that recombinant empty capsids of SV40, Virus Like Particles (VLPs), may attenuate ARDS, increasing survival and recovery from this severe clinical condition. We used the rat 2CLP (cecal ligation and two punctures) model for sepsis-induced ARDS. The VLPs, or vehicle (saline) control, were administered in 3 equal portions (total dose 0.3 mg/kg VLPs, in saline) for 3 days prior to the 2CLP operation. 2CLP was performed 24 hours later. While 100 the untreated rats died in 4 days, 75 of the VLP-treated ones survived. During the first 48 hours the treated rats presented similar symptoms and weight loss to the untreated ones. However afterwards their deterioration decelerated and they proceeded to full recovery. Lung pathology was normal in both treated and untreated rats sacrificed 24 hours after the 2CLP operation

• Creator/s: Defense Technical Information Center
• Date: 4/1/2017
• Year: 2017
• Book Topics/Themes: DTIC Archive, Oppenheim, Ariella, Hebrew University of Jerusalem Jerusalem Israel, lung, RESPIRATORY TRACT DISEASES, VIRUSES, therapeutics, immunity, sepsis, infection control

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