DTIC ADA058323: Mammalian Toxicological Evaluation of DIMP pdf

DTIC ADA058323: Mammalian Toxicological Evaluation of DIMP

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DIMP had oral LD50’s of 1125 and 825 mg/kg in male and female rats, respectively, and of 1041 and 1363 mg/kg in male and female mice. It was somewhat irritant to rabbit eyes. It was minimally irritant to rabbit skin, but produced systemic toxicity when applied to the skin. It was not a strong sensitizer in guinea pigs. No evidence of toxicity followed its dietary administration for 90 days to rats at levels up to 3000 ppm or to mice at levels up to 2100 ppm. At 1500 ppm dogs were not affected in 14 days. DIMP appeared to induce liver enzyme activity as manifest by diminished response to hexobarbital. It was reasonably well absorbed following oral administration, widely distributed and excreted, primarily in the urine, both unchanged and as two metabolites in rodents and three in dogs. DCPD had oral LD50’s of 520 and 378 mg/kg in male and female rats, respectively, and of 190 and 250 mg/kg in male and female mice.

It produced conjunctival irritation when applied to rabbit eyes. It was minimally irritant to rabbit skin and did not produce evidence of systemic toxicity when so applied. It was not a sensitizer in guinea pigs. No evidence of toxicity followed its dietary administration for 90 days to rats at levels up to 750 ppm or to mice at levels up to 273 ppm

• Creator/s: Defense Technical Information Center
• Date: 11/1/1976
• Year: 1976
• Book Topics/Themes: DTIC Archive, Hart, E Ross, LITTON BIONETICS INC KENSINGTON MD, *TOXICITY, *PHOSPHONATES, *CYCLIC COMPOUNDS, *PENTADIENES, MAMMALS, RATS, METHYL RADICALS, EYE, MICE, LIVER, SKIN(ANATOMY), RABBITS, PROPYL RADICALS, GUINEA PIGS

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