DTIC ADA1018293: Evaluation of Selected Subacute Effects pdf

DTIC ADA1018293: Evaluation of Selected Subacute Effects

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Juvenile bluegills were exposed to 0.05 mg/L, 0.50 mg/L, 1.0 mg/L, 2.0 mg/L, 4.0 mg/L, 5.0 mg/L and 8.0 mg/L 2,4-DNT for eight weeks. Both first and second order growth constants indicated reduced growth rates with increasing 2,4-DNT concentration. The threshold concentration for significant growth rate reduction was 0.05 mg/L 2,4-DNT. No histological abnormalities were found in the digestive tract, pancreas, integument, heart, gonad, head kidney and spinal cord. Significant histopathological responses were observed in liver, spleen, trunk kidney, lateral line and gill in fish exposed to 0.5 mg/L – 8.0 mg/L 2,4-DNT for 45 – 56 days. The 2,4-DNT was rapidly absorbed (24-96 hours), reached relatively low bioconcentration levels and was rapidly eliminated (24-72 hours) when fish were placed in 2,4-DNT free environment. (Author

• Creator/s: Defense Technical Information Center
• Date: 3/1/1981
• Year: 1981
• Book Topics/Themes: DTIC Archive, Hartley, William Ralph, TULANE UNIV NEW ORLEANS LA SCHOOL OF PUBLIC HEALTH AND TROPICAL MEDICINE, *TOXIC AGENTS, *EXPOSURE(PHYSIOLOGY), *DNT, *OSTEICHTHYES, TISSUES(BIOLOGY), LABORATORY TESTS, GROWTH(GENERAL), PHYSIOLOGICAL EFFECTS, SPLEEN, LIVER DISEASES, BIOASSAY, CARDIOVASCULAR DISEASES, FISH GILLS, SUBLETHAL DOSAGE, KIDNEY DISEASES

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