DTIC ADA142442: The Effects of Hyperbaric Pressure pdf

DTIC ADA142442: The Effects of Hyperbaric Pressure

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In vitro preparations of the nicotinic acetylcholine receptor from rat muscle and eel electroplax were chemically and pharmacologically characterized and then subjected to compression/decompression to/from 800 psi. Pressure causes a reversible decrease in cholinergic agent binding to the receptor. This decrease is prevented if agents such as hexamethonium and diisopropylfluorophosphate are present. These studies imply that pressure effects on molecular interactions at neural receptors could account for hyperbaric neurological disorders. In addition, hyperbaric therapy could be successful in cases of toxin and organophosphorus agent intoxication. (Author

• Creator/s: Defense Technical Information Center
• Date: 6/1/1984
• Year: 1984
• Book Topics/Themes: DTIC Archive, Taylor, R F, LITTLE (ARTHUR D) INC CAMBRIDGE MA, *NERVES, *NEUROPHYSIOLOGY, *HYPERBARIC CONDITIONS, *ACETYLCHOLINE, COMPRESSION, RATS, LIPIDS, PROTEINS, IN VITRO ANALYSIS, FLUORINE, LIGANDS, THERAPY, MOLECULE MOLECULE INTERACTIONS, MUSCLES, CHOLINESTERASE INHIBITORS, ORGANIC PHOSPHORUS COMPOUNDS, CHOLINERGIC NERVES, DECOMPRESSION, ORGANS(ANATOMY), PHOSPHATES, PROPYL RADICALS, INTOXICATION, EELS, NEUROCHEMICAL TRANSMISSION

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