DTIC ADA177817: Fundamental Studies in the Molecular pdf

DTIC ADA177817: Fundamental Studies in the Molecular

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This report describes the advances made in work for the Ocular Hazards Program. Research has seen the first application of femtosecond lasers to the visual system. We have discovered that anions can activate visual photoreceptors in the dark. One anionic activator is the commonly used dental agent fluoride. The data on in vitro preparations indicate that these anions modulate photoreceptor biochemistry and may effect photoreceptors sensitivity. The image of various elements in photoreceptors and adjacent tissues were identified. The spatial images should play important roles in extending our understanding of the fundamental mechanisms of laser damage. Complementary techniques have been developed to view, in light microscopy, actin filaments in photoreceptors. The staining procedures we have developed can be applied to study laser damaged retina. The protective nature of oil droplets in the turtle has been studied. Data demonstrating rapid mechanical motions in vertebrate photoreceptors has been obtained.

Such rapid mechanical motions which parallel electrophysiological responses in the cell may lie at the very basis of photoreceptor function. Laser damage mechanisms should be reevaluated in terms of this new data. The effect of laser light on these newly discovered mechanical motions will surely lead to new and improved understandings of low level laser ocular hazards

• Creator/s: Defense Technical Information Center
• Date: 4/1/1985
• Year: 1985
• Book Topics/Themes: DTIC Archive, Lewis, Aaron, CORNELL UNIV ITHACA NY SCHOOL OF APPLIED AND ENGINEERING PHYSICS, *RETINA, *LASER HAZARDS, *LASER DAMAGE, SPATIAL DISTRIBUTION, MECHANICAL PROPERTIES, ACTIVATION, TISSUES(BIOLOGY), HAZARDS, LIGHT, MOTION, SENSITIVITY, LASER BEAMS, MICROSCOPY, IMAGES, DROPS, VERTEBRATES, FILAMENTS, VISION, PARALLEL ORIENTATION, OILS, FLUORIDES, ANIONS, DENTISTRY, ELECTROPHYSIOLOGY, PHOTORECEPTORS, TURTLES, ACTINIUM

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