DTIC ADA204320: Effects of Biosynthetic Human Epidermal pdf

DTIC ADA204320: Effects of Biosynthetic Human Epidermal

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The ability of physicians to stimulate healing of mid-dermal injuries and incision in the skin is mainly limited at present to preventing infection and providing proper opposition of wound margins. The major goals of this contract are to elevate the actions of biosynthetic peptide growth factors on stimulating healing of mid-dermal injuries and incisions to the skin. We conducted a prospective, randomized, double-blind clinical study on the effects of biosynthetic epidermal growth factor (EGF) on paired donor sites. EGF treatment significantly (p0.003) accelerated healing compared to paired donor sites treated with Silvidene vehicle and decreased time to complete healing by approximately 2 days. We also found that EGF treatment stimulated healing of perforations in tympanic membrane. Testing another growth factor, we found that a single application of transforming growth factor beta (TGF-b) increased the tensile strength of surgical incisions in rats during the early period of healing.

These results demonstrate that peptide growth factors can accelerate healing of several types of wounds and indicate the need for further investigations on the effects of growth factors on other wounds such as chronic ulcers and expanded mesh autografts

• Creator/s: Defense Technical Information Center
• Date: 12/1/1987
• Year: 1987
• Book Topics/Themes: DTIC Archive, Schultz, Gregory, LOUISVILLE UNIV KY SCHOOL OF MEDICINE, *EPIDERMIS, *BIOSYNTHESIS, *GROWTH(GENERAL), PEPTIDES, MESH, WOUNDS AND INJURIES, EXPANSION, INFECTIOUS DISEASES, PHYSICIANS, ACCELERATED TESTING, TRANSPLANTATION, EAR, HEALING, RATS, ULCERS, TENSILE STRENGTH, STIMULATION(GENERAL

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