DTIC ADA404589: The Role of Histone Deacetylase pdf

DTIC ADA404589: The Role of Histone Deacetylase

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The proposal tests the hypothesis that histone deacetylase activity contributes to the transcriptional repression of the methylated estrogen receptor a (ER) gene. It further postulates that inhibition of histone deacetylase (HDAC) and DNA methylation may act together to reactivate the ER gene. Studies to date show that the HDAC inhibitor trichostatin A, can reactivate ER expression in ER- negative breast cancer cell lines. Combined studies with HDAC inhibitors and demethylating agents are in progress

• Creator/s: Defense Technical Information Center
• Date: 6/1/2001
• Year: 2001
• Book Topics/Themes: DTIC Archive, Huang, Yi, JOHNS HOPKINS UNIV BALTIMORE MD SCHOOLOF MEDICINE, *RECEPTOR SITES(PHYSIOLOGY), *ESTROGENS, *BREAST CANCER, TEST AND EVALUATION, HYPOTHESES, INHIBITION, METHYLATION, HISTONES

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