DTIC ADA434550: Caveolin 1 Modulates Androgen Receptor pdf

DTIC ADA434550: Caveolin 1 Modulates Androgen Receptor

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In the past three years, we identified and preliminarily characterized a novel serine/threonine p21 activated protein kinase 6 (PAK 6) as the key signal mediator in regulating AR signal transduction within caveolae/raft domain. We also demonstrated a cross-talk between the caveolin-1/AR and PI3 kinase/Akt signal pathway in hormone dependent cell survival. Overall, our results established a biochemical basis on the notion that caveolin expression is associated with prostate cancer progression. The neoexpression caveolin in prostate cancer progression represents a gain of function event in cancer survival. These results illustrate the important role of AR non-genomic effect in response to androgen stimulation. Moreover, the identification of a novel serine/threonine PAK6 kinase underscores the relevance of this signal pathway in mediating AR nongenomic effects. Our results support the hypothesis from our original proposal that AR signals from rafts to regulate its transcriptional function. These findings pave the way to further define the underlying signal cross-talk in AR-mediated signaling

• Creator/s: Defense Technical Information Center
• Date: 2/1/2005
• Year: 2005
• Book Topics/Themes: DTIC Archive, Lu, Michael L, BRIGHAM AND WOMEN’S HOSPITAL BOSTON MA, *ANDROGENS, *PROSTATE CANCER, HORMONES, STIMULATION(PHYSIOLOGY), SURVIVABILITY, HYPOTHESES, RESPONSE(BIOLOGY), CELLS(BIOLOGY), CROSSTALK, GROWTH(PHYSIOLOGY), PROSTATE GLAND, TRANSCRIPTION(GENETICS

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