DTIC ADA442827: Physiologic and Endocrine Correlates of pdf

DTIC ADA442827: Physiologic and Endocrine Correlates of

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Description of the Book:

Obesity has reached epidemic levels and yet the incidence continues to rise. The current study is seeking to examine the hypothesis that obesity may reflect dysfunctioning of the hypothalamic-pituitary-adrenal (HPA) axis in response to stressors. African American persons are at greatest risk, but reasons for this difference are unknown. We will study 120 men and women of Caucasian and African American ethnicity and examine their responses to physiologic stressors: exercise and ingestion of a meal. The HPA axis will be studied in some detail by using two stressor paradigms and two steroid regimens. We expect to be able to detect subtle differences in HPA axis reactivity in obese individuals and that might contribute to morbidity and perhaps even make individuals resistant to therapeutic interventions. We have enrolled 63 participants, with 46 completed. Data collection and analyses are proceeding on schedule. Two abstracts were submitted and accepted for presentation in Summer 2005.

We are on schedule for all milestones for this study and look forward to being able to answer the important questions regarding the potential role of the HPA axis in obesity

• Creator/s: Defense Technical Information Center
• Date: 3/1/2005
• Year: 2005
• Book Topics/Themes: DTIC Archive, Deuster, Patricia A, HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE ROCKVILLE MD, *PHYSIOLOGY, *METABOLIC DISEASES, *OBESITY, *ENDOCRINOLOGY, MEALS, INTERVENTION, INSULIN, EXERCISE(PHYSIOLOGY), MORBIDITY, EPIDEMIOLOGY, ETHNIC GROUPS

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