DTIC ADA460347: DNA Precursor Metabolism and Mitochondrial pdf

DTIC ADA460347: DNA Precursor Metabolism and Mitochondrial

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This project investigated DNA precursor metabolism in mammalian mitochondria, attempting to define relationships between deoxyribonucleoside triphosphate (dNTP) metabolism and mutagenesis in the mitochondrial genome. Specific contributions include: (1) We found that conditions altering the normal balance among the four dNTP pools within the mitochondrion stimulate both point and deletion mutagenesis; (2) dNTP pools in mitochondria from some tissues are highly asymmetric contributes toward the elevation of mitochondrial mutation rates compared to nuclear muation rates; (3) Mitochondrial dNTP pools do not show significant age-related changes in the rat, ruling out such changes as causative agents in aging-related accumulation of mitochondrial mutations; (4) A protein previously identified as a mitochondrial deoxyribmucleotide carrier, responsible for dNTP uptake into mitochondria, plays a quite different metablic role; (5) Mammalian mitochondria contain a novel ribonucleotide reductase, which may play a sinificant role in mitochondrial dNTP synthesis

• Creator/s: Defense Technical Information Center
• Date: 4/1/2003
• Year: 2003
• Book Topics/Themes: DTIC Archive, Mathews, Christopher K, OREGON STATE UNIV CORVALLIS OFFICE OF SPONSORED PROGRAMS, *STABILITY, *DEOXYRIBONUCLEIC ACIDS, *MITOCHONDRIA, *GENOME, SYNTHESIS, PRECURSORS, RIBONUCLEOTIDES, MUTATIONS, ENZYMES, PROTEINS, METABOLISM

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