-
Book Title: DTIC ADA462791: Beta catenin: A Potential Survival
-
Book Category: EPITHELIUM
-
Language: english
-
Post Date: 2025-04-03 16:44:30
-
PDF Size: 3.47 MB
-
Book Pages: 112
-
Read Online: Read PDF Book Online
-
PDF Download: Click to Download the PDF
- Tags:
DTIC ADA462791: Beta catenin: A Potential Survival
More Book Details
Description of the Book:
The Wnt/ -catenin pathway has been extensively studied for its role in development and cancer. The canonical Wnt signal is transduced by -catenin, which acts as a transcriptional coactivator by associating with the Tcf/LEF family of transcription factors. It has been established that Wnt signaling regulates the self-renewal of normal stem cells in both the hematopoietic systems and the epidermis. In addition, constitutive activation of the Wnt pathway has been implicated in a number of epithelial cancers, possibly by promoting stem cell survival. However, the importance of this pathway in breast stem/progenitor cells has not yet been elucidated. Objective/Hypothesis: The central hypothesis of this study is that the Wnt/ -catenin pathway plays a critical role in mammary gland stem cell survival, and as a result promotes tumorigenesis and resistance to conventional therapies
- Creator/s: Defense Technical Information Center
- Date: 9/1/2006
- Year: 2006
- Book Topics/Themes: DTIC Archive, Rosen, Jeffrey M, BAYLOR COLL OF MEDICINE HOUSTON TX, *BREAST CANCER, ACTIVATION, EPITHELIUM, SURVIVABILITY, PRECURSORS, RESISTANCE, NEOPLASMS, THERAPY, STEM CELLS, HYPOTHESES, SURVIVAL(PERSONNEL), CELLS(BIOLOGY), HEMATOPOIETIC SYSTEM, CANCER, EPIDERMIS, MAMMARY GLANDS
Leave a Reply