DTIC ADA462791: Beta catenin: A Potential Survival pdf

DTIC ADA462791: Beta catenin: A Potential Survival_bookcover

DTIC ADA462791: Beta catenin: A Potential Survival

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The Wnt/ -catenin pathway has been extensively studied for its role in development and cancer. The canonical Wnt signal is transduced by -catenin, which acts as a transcriptional coactivator by associating with the Tcf/LEF family of transcription factors. It has been established that Wnt signaling regulates the self-renewal of normal stem cells in both the hematopoietic systems and the epidermis. In addition, constitutive activation of the Wnt pathway has been implicated in a number of epithelial cancers, possibly by promoting stem cell survival. However, the importance of this pathway in breast stem/progenitor cells has not yet been elucidated. Objective/Hypothesis: The central hypothesis of this study is that the Wnt/ -catenin pathway plays a critical role in mammary gland stem cell survival, and as a result promotes tumorigenesis and resistance to conventional therapies

  • Creator/s: Defense Technical Information Center
  • Date: 9/1/2006
  • Year: 2006
  • Book Topics/Themes: DTIC Archive, Rosen, Jeffrey M, BAYLOR COLL OF MEDICINE HOUSTON TX, *BREAST CANCER, ACTIVATION, EPITHELIUM, SURVIVABILITY, PRECURSORS, RESISTANCE, NEOPLASMS, THERAPY, STEM CELLS, HYPOTHESES, SURVIVAL(PERSONNEL), CELLS(BIOLOGY), HEMATOPOIETIC SYSTEM, CANCER, EPIDERMIS, MAMMARY GLANDS

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