DTIC ADA466565: Identification of Sonic Hedgehog Induced pdf

DTIC ADA466565: Identification of Sonic Hedgehog Induced

More Book Details

Description of the Book:

We will determine the mechanism by which Shh signaling accelerates prostate tumor growth, identify Shh targets in prostate tumor stroma, and test the effect of individual target genes on tumor growth. The purpose of the report is to evaluate the first year of research. Sonic hedgehog induces tumor growth by a paracrine mechanism using tumor stroma. Shh signaling independent of Shh ligand in tumor stroma accelerates tumor growth. We have identified potential stromal Shh target genes in xenograft tumors and have begun to evaluate the genes in human prostate cancer. Noggin was identified as a Shhinduced paracrine factors that may drive tumor growth by interfering with BMP signaling. Noggin was overexpressed in tumor stroma. Stromal-derived Noggin does not accelerate tumor growth in the presence or absence of Shh. Future research will continue to identify and evaluate Shh-induced paracrine factors that accelerate prostate tumor growth

• Creator/s: Defense Technical Information Center
• Date: 11/1/2006
• Year: 2006
• Book Topics/Themes: DTIC Archive, Shaw, Aubie, WISCONSIN UNIV-MADISON, *PROSTATE CANCER, EPITHELIUM, NEOPLASMS, GENES, CELLS(BIOLOGY), GROWTH(PHYSIOLOGY), PROSTATE GLAND

An excerpt captured from the PDF book