DTIC ADA474599: A Novel Strategy for Controlling pdf

DTIC ADA474599: A Novel Strategy for Controlling

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Description of the Book:

BCRP Award has funded fundamental new discoveries into how a key protein involved in the metastatic process of breast cancer functions. We have discovered the following: 1. The SNAIL zinc finger repressor must bind its obligate co-repressor AJUBA, in order to repress e-cadherin and initiate metastasis. 2. The AJUBA interaction is direct and highly specific and this complex can be found at endogenous SNAIL target genes. 3. The binding requires the 20 amino acid SNAG domain of SNAIL and a single LIM domain of AJUBA. This biding forms a well-defined protein-protein interaction, which may be targeted by small molecules to interfere with the metastatic process during breast cancer progression

• Creator/s: Defense Technical Information Center
• Date: 7/1/2007
• Year: 2007
• Book Topics/Themes: DTIC Archive, Rauscher, III, Frank J, PENNSYLVANIA UNIV PHILADELPHIA WISTAR INST, *PROTEINS, *IN VITRO ANALYSIS, *IN VIVO ANALYSIS, *BREAST CANCER, *METASTASIS, FUNCTIONS, TARGETING, FINGERS, SNAILS, GENES, ZINC, TARGETS

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