DTIC ADA477284: Trials of Anti PSMA Designer pdf

DTIC ADA477284: Trials of Anti PSMA Designer

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Anti-PSMA designer T cells Autologous T cells that are gene-modified to express chimeric immunoglobulin T cell receptors (TgTCR) that recognize the prostate specific membrane antigen. We will conduct Phase I dose-escalation trial with infusion of designer T cells into prostate cancer patients after non-myeloablative (NMA) conditioning. This procedure will allow for the stable engraftment and persistence of the infused cells for improved therapeutic effect. The first year efforts have been in preparation of a clinical-grade vector producer cell (VPC) line, production and testing of clinical vector supernatants and in harmonizing IRB-recommended protocol modifications and completing administrative features in advance of the trial. In year 2 the vector was received from NGVL after production delay. Patients will commence enrollment in year 3 January 2008

• Creator/s: Defense Technical Information Center
• Date: 7/1/2007
• Year: 2007
• Book Topics/Themes: DTIC Archive, Junghans, Richard P, ROGER WILLIAMS MEDICAL CENTER PROVIDENCE RI, *MEMBRANES(BIOLOGY), *T LYMPHOCYTES, *PROSTATE CANCER, GENES, ANTIGENS, RECEPTOR SITES(PHYSIOLOGY), PROSTATE GLAND

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