DTIC ADA494507: Programmed Pathogen Sense and Destroy pdf

DTIC ADA494507: Programmed Pathogen Sense and Destroy

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Description of the Book:

We are creating an anti-microbial sense-and-destroy system by engineering sentinel/killer cells that detect the presence of pathogenic bacteria, report the identity of the pathogen with a coded output signal, and secrete specific bacteriocins/lysins that destroy the pathogen. Engineering cells for detection and targeted destruction of pathogens offers a single integrated solution to eradicate multiple threats with an approach that is a rapid, selective, and highly sensitive. We are engineering a single cell type that detects chemical signals naturally produced by different classes of pathogens and initiates multiple specific responses, each tailored to particular members of the classes. The system will thus be able to analyze environmental conditions and execute an intelligent response by utilizing multiple, customized treatments

• Creator/s: Defense Technical Information Center
• Date: 2/18/2009
• Year: 2009
• Book Topics/Themes: DTIC Archive, Weiss, Ron, TRUSTEES OF PRINCETON UNIV NEW JERSERY, *CIRCUITS, *PATHOGENESIS, CELLS, RESPONSE, ANTIMICROBIAL AGENTS, PATHOGENIC MICROORGANISMS, BACTERIA, DETECTION, SIGNALS

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