DTIC ADA506361: Imaging Heat Shock Protein 90 pdf

DTIC ADA506361: Imaging Heat Shock Protein 90

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During the first year of the funding period, we have labeled 1, 3-propoyldiamine modified geldanamycin with both fluorescent core (FITC in this case) and radioisotopes. Unfortunately, in vitro cell experiments failed to disclose the ability of FITC-GM to monitor Hsp90 activity changes after heat stimulation in prostate cancer cell lines. Small molecular Hsp90 inhibitors, at least GM derivatives, showed reasonable tumor accumulation after being labeled with 64Cu. However, in vitro experiments revealed that the GM derivatives are insufficient to tell the changes of both Hsp90 level and activity after stimulation. It might be more appropriate to use GM imaging for tumor detection instead of Hsp90 activity monitoring

• Creator/s: Defense Technical Information Center
• Date: 3/1/2009
• Year: 2009
• Book Topics/Themes: DTIC Archive, , LELAND STANFORD JUNIOR UNIV CA, *PROTEINS, *PROSTATE CANCER, DETECTION, RADIOACTIVE ISOTOPES, NEOPLASMS, CELLS(BIOLOGY), HORMONES, IMAGE PROCESSING

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