DTIC ADA553097: The Utility of Human Plasma pdf

DTIC ADA553097: The Utility of Human Plasma

More Book Details

Description of the Book:

The aim of this study was to demonstrate, in guinea-pigs in vivo, the utility of huBuChE as a therapy against percutaneous (p.c.) nerve agent poisoning, following which there is a slower absorption of agent than by the inhalation route and consequently a longer window of opportunity for therapeutic intervention. The p.c. toxicity of VR was determined in Dunkin- Hartley guinea-pigs. The 24h LD50 was 0.45mg/kg (0.36 0.54 95% CI) and the 48-h LD50 was 0.38 mg/kg (0.31-0.45 95% CI). We used a telemetered guinea-pig model to assess the efficacy of post-exposure therapy using huBuChE. When therapy was administered by the intramuscular (i.m.) route within 2h of VR poisoning (1.6 LD50), high protection levels were achieved; 87.5% (7/8) of guinea-pigs survived to 7 days. Delaying the administration of huBuChE to the onset of systemic cholinergic signs of poisoning dramatically reduced the survival rate to 3/8 animals. Therapy using huBuChE via the intravenous (i.v.) route improved the survival rate compared to therapy via the i.m.

route; 7/8 animals survived to the end of the experiment at 7 days. The physiological data suggest that huBuChE acts by preventing or mitigating the detrimental changes seen following p.c. VR exposure, e.g. seizure, hypothermia, bradycardia

• Creator/s: Defense Technical Information Center
• Date: 10/1/2011
• Year: 2011
• Book Topics/Themes: DTIC Archive, , DEFENSE SCIENCE AND TECHNOLOGY LAB SALISBURY (UNITED KINGDOM), *NERVE AGENTS, *POISONING, ANIMALS, EXPOSURE(PHYSIOLOGY), IN VIVO ANALYSIS, INHALATION, MODELS, MUSCLES, PROTECTION, RATES, REDUCTION, SKIN(ANATOMY), SURVIVAL(PERSONNEL), TELEMETER SYSTEMS, THERAPY, TOXICITY, VEINS

An excerpt captured from the PDF book