DTIC ADA573586: Glycomic Analysis of Prostate Cancer pdf

DTIC ADA573586: Glycomic Analysis of Prostate Cancer

More Book Details

Description of the Book:

In this proposal, we are testing the hypothesis that the risk of developing prostate cancer and the aggressiveness of the disease are influenced by protein glycosylation. We postulate that glycobiology contributes to the higher susceptibility of African American men. The study population is assembled and an annotated sample repository is ready for use. Methods for the glycomic analysis of fractionated proteins are in place. We have evaluated mRNA datasets comparing prostate cancer in African American and Caucasian men. The analysis finds some connections to glycosylation. We have now analyzed pooled and unpooled samples of men by optimized analyses of fractionated serum in order to evaluate the glycomic changes in prostate cancer health disparity. The analysis and the interpretation of results is ongoing

• Creator/s: Defense Technical Information Center
• Date: 7/1/2011
• Year: 2011
• Book Topics/Themes: DTIC Archive, , GEORGETOWN UNIV WASHINGTON DC, *GLYCOSIDES, *PROSTATE CANCER, AFRICAN AMERICANS, BLOOD SERUM, CAUCASIANS, DISEASES, HEALTH, PROTEINS, RISK

An excerpt captured from the PDF book