DTIC ADA582352: Molecular Signatures and Diagnostic Biomarkers pdf

DTIC ADA582352: Molecular Signatures and Diagnostic Biomarkers

More Book Details

Description of the Book:

Objectives of the entire project are: (i) Develop an experimental framework for reproducing multiple blast wave exposures and recording multiple blasts in an animal model using a prototype sensor device, (ii) define cumulative blast load upon multiple blast exposures and distinguish pathophysiological mechanisms of mild through severe TBI to formulate blast load injury scale, (iii) identify and validate biochemical markers of cumulative blast exposures. In year 1, we determined blast load characteristics producing mild through severe TBI and defined composite and primary blast parameters. Schlieren optics technique was used to visualize blast wave interaction with experimental animal. The pathological effects of primary blast OP exposure of controlled duration, peak pressure and transmitted impulse were compared with brain injury by a severe blast load accompanied with strong head acceleration. We assessed and partially characterized brain injury signatures when primary blast wave hits frontal head with open or covered body vs.

composite blast: neuro-glial injury evaluated by silver staining, and GFAP/CNPase and NSE. Biomarkers of neuro-glial injury GFAP, CNPase and NSE were accumulated in circulation in a particular time-dependent fashion. We developed a v1.1 of sensor package for detecting/recording a cumulative blast exposure, and begin to characterize mechanisms and biomarkers of brain injury in response to multiple mild/moderate blast exposures

• Creator/s: Defense Technical Information Center
• Date: 10/1/2012
• Year: 2012
• Book Topics/Themes: DTIC Archive, , BANYAN BIOMARKERS INC ALACHUA FL, *TRAUMATIC BRAIN INJURIES, BIOCHEMISTRY, BLAST WAVES, DIAGNOSIS(MEDICINE

An excerpt captured from the PDF book