DTIC ADA599223: Spinal Cord Repair with Engineered pdf

DTIC ADA599223: Spinal Cord Repair with Engineered

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Description of the Book:

Spinal cord injury (SCI) exacts an enormous social and financial burden on society. As such, there has been considerable attention directed at finding treatment strategies, including development of tissue and cell transplant techniques. However, the current approaches do not adequately address the complexity of the injury site, such as lesion length and an environment that is usually non-permissive for axon regeneration. We have developed tissue engineered nerve grafts (TENGs) consisting of living dorsal root ganglia (DRG) and axons that can be stretch-grown to a length necessary to bridge extensive lesions. In current studies, we have optimized in vivo laminoplasty procedures, transplanted stretch-grown constructs into a 5 mm-long lesion in the rat thoracic spinal cord, and have demonstrated survival of DRGs up to 6 weeks post-transplant. We intend to evaluate long-term (3 and 6 month) survival of the constructs as well as functional recovery beyond the lesion site.

If successful, this approach will provide an alternative or additional means to repair large spinal lesions

• Creator/s: Defense Technical Information Center
• Date: 10/1/2013
• Year: 2013
• Book Topics/Themes: DTIC Archive, , PENNSYLVANIA UNIV PHILADELPHIA, *SPINAL CORD, *TISSUES(BIOLOGY), *WOUNDS AND INJURIES, ENVIRONMENTS, IN VIVO ANALYSIS, LESIONS, MEDICAL RESEARCH, NERVE FIBERS, NERVES, OPTIMIZATION, RECOVERY, REPAIR, SPINAL COLUMN, SURGICAL TRANSPLANTATION, THORAX

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