DTIC ADA610026: Role of IKKalpha in the pdf

DTIC ADA610026: Role of IKKalpha in the

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Overexpression of EGFR is frequently linked to more aggressive tumor behavior, including increased proliferation, metastasis, and therapeutic resistance. Here, we identified a molecular linkage between IKKalpha and EGFR signaling in breast cancer cells. Inhibition of IKKs activity elevates EGFR tyrosine phosphorylation. In addition, IKK! forms a specific interaction with EGFR in Golgi apparatus and catalyzes EGFR S1026 phosphorylation. We found that EGFR S1026A possess a stronger tumorgenesis phenotype compare with wild type EGFR suggesting a negative regulation of IKK! in EGFR signaling. In agreement with an earlier finding where conditional ablation of IKKalpha in the mice Keratinocytes elevates the autocrine loop of EGFR, our results further provide a potent role of IKKalpha kinase activity in preservation of EGFR activity

• Creator/s: Defense Technical Information Center
• Date: 9/1/2011
• Year: 2011
• Book Topics/Themes: DTIC Archive, , M D ANDERSON CANCER CENTER HOUSTON TX, *BREAST CANCER, *EPIDERMIS, *METASTASIS, *PHOSPHORUS TRANSFERASES, AGREEMENTS, BEHAVIOR, CELL STRUCTURE, INTERACTIONS, NEOPLASMS, PHOSPHORYLATION, TYROSINE

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