DTIC ADA627614: A Novel Biologic Hemostatic Dressing pdf

DTIC ADA627614: A Novel Biologic Hemostatic Dressing

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This study evaluated the efficacy of a biologic hemostatic fibrin patch (FP) to control coagulopathic bleeding and prevent death in a porcine model of severe liver injury with hemodilution and hypothermia. Methods: Coagulopathy was produced in swine by exchanging 60% of the animals circulating blood volume with Hextend and lowering the core temperature to 32.0 Degrees C + or – 0.5 Degrees C. A grade V liver injury was induced and allowed to bleed freely for 30 seconds (pretreatment blood loss). Animals were randomly divided into three treatment groups: hepatic packing (HP) using laparotomy sponges, FP application plus HP, or placebo patch (PP) application plus HP. Animals were resuscitated to 80% of the preinjury mean arterial pressure. Core temperature, mean arterial pressure, and survival were monitored for 1 hour postinjury. Packs were removed from the animals that survived to 1 hour and they were monitored for an additional hour.

Results: Coagulopathy was confirmed by significant increases (p less than 0.01) in prothrombin time, activated partial thromboplastin time, and activated clotting time in preinjury measurements as compared with baseline values. Pretreatment blood loss was not different among the groups. However, significant p less than 0.01) differences were observed in the posttreatment blood loss (772 mL + or – 340 mL, 4,977 mL + or – 440 mL, 4,173 mL + or – 608 mL), as well as the required fluid resuscitation volume (994 mL + or – 26 mL, 4,083 mL + or – 185 mL, 3,494 mL + or – 492 mL), between FP versus PP or HP groups, respectively. In addition, 89% of FP animals survived the 2-hour observation with an average survival time of 111 minutes 9 minutes, which was significantly higher than the PP (0% survival, 39 minutes 4 minutes) or HP (13% survival, 41 minutes 12 minutes) groups

• Creator/s: Defense Technical Information Center
• Date: 1/1/2008
• Year: 2008
• Book Topics/Themes: DTIC Archive, , ARMY INST OF SURGICAL RESEARCH FORT SAM HOUSTON TX, *BLOOD COAGULATION, *DRESSINGS, *FIBRIN, *LIVER, *WOUNDS AND INJURIES, ACIDOSIS, BLOOD CELLS, BLOOD PLATELETS, BLOOD PRESSURE, CASUALTIES, CATIONS, CLINICAL MEDICINE, DAMAGE CONTROL, FLUIDS, HYPOTHERMIA, MORTALITY RATE, PROTHROMBIN, SPONGES, SURGICAL SUPPLIES, SURVIVABILITY, SWINE, THROMBOPLASTIN, TRAUMA

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