DTIC ADP014409: Tissue Engineering of Fibroblast Constructs pdf

DTIC ADP014409: Tissue Engineering of Fibroblast Constructs

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The creation of an in vitro functional tendon construct will enable testing of the influence of mechanics and nutrients on the development and remodeling of tendon under known controlled stimuli which is difficult to achieve in vivo. Tendon constructs were engineered in vitro via stress-mediated self organization of fibroblasts and ECM on a laminin coated elastomer substrate. Varying the laminin density and the amount of fetal bovine serum on the substrate affected the ability of tendon fibroblasts to form a confluent cell layer and the time to layer delamination. Understanding the factors that promote selfassembly of tendon constructs will enable their combination with already developed in vitro muscle constructs

• Creator/s: Defense Technical Information Center
• Date: 4/1/2002
• Year: 2002
• Book Topics/Themes: DTIC Archive, Calve, Sarah, Arruda, Ellen, Dennis, Robert, Grosh, Karl, Pasyk, Krystyna, MICHIGAN UNIV ANN ARBOR, *TISSUES(BIOLOGY), *IN VITRO ANALYSIS, *ANISOTROPY, *FIBROBLASTS, *GELS, *COLLAGEN, SKILLS, CELLS, NUTRIENTS, MECHANICS, STIMULI, MUSCLES, BLOOD SERUM, IN VIVO ANALYSIS, ELECTRONIC COUNTERMEASURES, BOVINES, FETUS, TENDONS

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