NASA Technical Reports Server (NTRS) : The pdf

NASA Technical Reports Server (NTRS) : The

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Animal cells face a variety of environmental stresses in large scale bioreactors, including periodic variations in shear stress and dissolved oxygen concentration. Diagnostic techniques were developed for identifying the particular sources of environmental stresses for animal cells in a given bioreactor configuration. The mechanisms by which cells cope with such stresses was examined. The individual concentrations and synthesis rates of hundreds of intracellular proteins are affected by the extracellular environment (medium composition, dissolved oxygen concentration, ph, and level of surface shear stress). Techniques are currently being developed for quantifying the synthesis rates and concentrations of the intracellular proteins which are most sensitive to environmental stress. Previous research has demonstrated that a particular set of stress response proteins are synthesized by mammalian cells in response to temperature fluctuations, dissolved oxygen deprivation, and glucose deprivation. Recently, it was demonstrated that exposure of human kidney cells to high shear stress results in expression of a completely distinct set of intracellular proteins

• Creator/s: NASA Technical Reports Server (NTRS
• Date: 10/1/1988
• Year: 1988
• Book Topics/Themes: NASA Technical Reports Server (NTRS), BIOREACTORS, CELLS (BIOLOGY), OXYGEN, PROTEINS, SHEAR STRESS, STRESS (PHYSIOLOGY), BIOTECHNOLOGY, CHEMICAL COMPOSITION, HYPEROXIA, PH, SPACE COMMERCIALIZATION, TEMPERATURE EFFECTS, Goochee, Charles F

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